Good Wholesale Vendors Ivermectin Injection - Nicolsamide tablet – Depond
Good Wholesale Vendors Ivermectin Injection - Nicolsamide tablet – Depond Detail:
Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.
Composition:
Each bolus cotnains 1250 mg niclosamide
Indication:
For ruminants infected paramphistomes, cestodiasis, such as cattle and sheep’s moniezia, avitellina centripunctata, etc.
Dosage and Usage:
Orally each 1kg body weight.
Cattle: 40-60mg
Sheep: 60-70mg
Withdrawal period:
Sheep: 28 days.
Cattle:28 days.
Package size: 5 tablet per blister, 10 blister per box
Product detail pictures:
Related Product Guide:
Our goal is to satisfy our customers by offering golden service, good price and high quality for Good Wholesale Vendors Ivermectin Injection - Nicolsamide tablet – Depond , The product will supply to all over the world, such as: Oman, Iraq, Amman, Our company has abundant strength and possesses a steady and perfect sales network system. We wish we could establish sound business relationships with all customers from at home and abroad on the basis of mutual benefits.
By Pamela from Colombia - 2018.12.28 15:18
The company comply with the contract strict, a very reputable manufacturers, worthy a long-term cooperation.
By Lulu from Sudan - 2018.07.27 12:26