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OEM Factory for Avermectin Bolus - Nicolsamide tablet – Depond

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Our aim is usually to give superior quality items at aggressive rates, and top-notch company to clients around the earth. We have been ISO9001, CE, and GS certified and strictly adhere to their good quality specifications for Florfenicol Oral Solution , 50ml Analgin Injection , Sheep Avermectin Tablet , We have more than 20 years experience in this industry, and our sales are well trained. We can give you the most professional suggestions to meet your products' requirements. Any troubles, come to us!
OEM Factory for Avermectin Bolus - Nicolsamide tablet – Depond Detail:

Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.

Composition:

Each bolus cotnains 1250 mg niclosamide

Indication:

For ruminants infected paramphistomes, cestodiasis, such as cattle and sheep’s moniezia, avitellina centripunctata, etc.

Dosage and Usage:

Orally each 1kg body weight.

Cattle: 40-60mg

Sheep: 60-70mg

Withdrawal period:

Sheep: 28 days.

Cattle:28 days.

Package size: 5 tablet per blister, 10 blister per box


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OEM Factory for Avermectin Bolus - Nicolsamide tablet – Depond detail pictures


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  • This is the first business after our company establish, products and services are very satisfying, we have a good start, we hope to cooperate continuous in the future!
    5 Stars By Penelope from Argentina - 2018.12.11 14:13
    The company comply with the contract strict, a very reputable manufacturers, worthy a long-term cooperation.
    5 Stars By Aurora from Bolivia - 2017.06.29 18:55
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