Original Factory 100ml Ivermectin Soluiton - Nicolsamide tablet – Depond
Original Factory 100ml Ivermectin Soluiton - Nicolsamide tablet – Depond Detail:
Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.
Composition:
Each bolus cotnains 1250 mg niclosamide
Indication:
For ruminants infected paramphistomes, cestodiasis, such as cattle and sheep’s moniezia, avitellina centripunctata, etc.
Dosage and Usage:
Orally each 1kg body weight.
Cattle: 40-60mg
Sheep: 60-70mg
Withdrawal period:
Sheep: 28 days.
Cattle:28 days.
Package size: 5 tablet per blister, 10 blister per box
Product detail pictures:
Related Product Guide:
All we do is usually connected with our tenet " Customer to start with, Rely on initial, devoting on the food packaging and environmental protection for Original Factory 100ml Ivermectin Soluiton - Nicolsamide tablet – Depond , The product will supply to all over the world, such as: Philadelphia, Senegal, Malaysia, We have advanced production technology, and pursuit innovative in goods. At the same time, the good service has enhanced the good reputation. We believe that as long as you understand our product, you need to be willing to become partners with us. Looking forward to your inquiry.
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By Karen from Saudi Arabia - 2018.07.12 12:19